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Clinical Studies
Developed by doctors
Proven effect
Produced in Denmark
Seen in
Wrinkle cream that actually works
Read more
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100%
Achieved improved skin elasticity
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96%
Experienced a reduced number of wrinkles
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96%
Achieved improved skin firmness
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88%
Experienced a reduction in wrinkle area
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88%
Experienced a reduction in wrinkle length
Before & After
Tora has been using products from Dr.Stine for 6 weeks
Before
After
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WHY DO WE TEST?
Clinical studies are your and our assurance that the products' efficacy and tolerability have been studied and confirmed by independent dermatologists, which provides a high degree of certainty that the results are valid.
Documented efficacy means that the products' effects have been studied and found valid in clinical studies conducted by an independent, third-party dermatological testing laboratory.
Dermatological means that the test results are examined and evaluated by dermatologists, i.e. skin doctors. Third-party and independent means that the testing laboratory is not involved in the development or sale of the products, and that their financial earnings are not affected by the results of the clinical studies.
In clinical studies of Dr.Stine products, the results are based on objective and quantifiable measurements performed by independent dermatologists.
Developed by doctors
Proven effect
Produced in Denmark
Clinical studies of Dr. Stine products are conducted by independent dermatologists at a third-party testing laboratory in Poland.
A total of 500 people have participated in the dermatological studies, all of which were conducted by independent specialists. The number of participants in each study varies, but we always strive to have a sufficient number of participants to achieve statistically significant results.
The test subjects received the product in a white test tube without a logo or name, so they do not know which product or skincare brand they are testing. The clinical studies have different designs depending on what is being studied.
In the long-term studies, the products were used as the only skin care product, morning and evening, daily for 8 weeks. The results were obtained by examining the test subjects' skin before and after the test period, including using advanced 3D skin scanners and other measuring instruments.
No placebo was used. Instead, the results in the efficacy studies were obtained by comparing them with the skin care routine that the test subjects used prior to the study.
“Skin irritation test” or “Skin tolerability test” is a dermatological test used to assess the skin's tolerance to a product.
Method:
The product is applied to the skin and covered with a protective membrane. This way, the moisture in the product is retained and the cream remains on the skin without drying out. This enhances the product's effect on the skin. The product remains on the skin for 48 hours, after which the membrane is removed.
The skin is assessed by an independent dermatologist 30 minutes after the occlusion/membrane is removed, and again after 72 hours. If there has been any sign of irritation, the skin of the test subject is assessed again after 96 hours. The dermatologist assesses whether there is any sign of irritation and looks for, among other things, redness, swelling, bumps, blisters and skin damage.
Based on the results, the product is classified as either:
- non-irritating
- slightly annoying
- moderately annoying
- very annoying
The test is in accordance with:
- Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products
- Cosmetics Europe – The Personal Care Association (formerly COLIPA) guidelines: “Product Test Guidelines for the Assessment of Human Skin Compatibility” (1997)
- Cosmetics Europe – The Personal Care Association (formerly COLIPA) guidelines for evaluating the efficacy of cosmetic products (2008)
WHO HAS THE PRODUCT BEEN TESTED ON?
Below is an example of results for WASH the day off facial cleanser:
The product has been dermatologically tested on 75 people aged 21 to 69.
9% (7 out of 75) of the test subjects were male, and 91% (68 out of 75) were female.
33% of the test subjects had known allergic/atopic (sensitive) skin.
The test subjects predominantly had skin phototype 2 (Fitzpatrick scale 2).
RESULT
All our products have been tested with a skin tolerability test . None of the test subjects showed signs of allergic reaction, irritation, redness or swelling – neither after 30 minutes nor after 72 hours. The products are well tolerated and can be classified as non-irritating , also for people with atopic/allergic (sensitive) skin.
Firmness and elasticity are biomechanical properties of the skin, which are measured using an advanced measuring instrument, the Cutometer® . The Cutometer® is one of the most recognized and widely used measuring instruments in dermatology for assessing skin firmness and elasticity.
The instrument creates a vacuum, or negative pressure, to which the skin is exposed for a short period of time. While the skin is exposed to the pressure changes, the instrument's optical components measure the skin's movements. The skin's resistance to movement when exposed to the suction is a measure of the skin's firmness. The skin's ability to return to its original shape when the suction is removed is a measure of the skin's elasticity.
Method
The test subjects are instructed to discontinue use of other facial creams, serums, etc. at the start of the test period. The test subjects apply the test product to their face twice daily as the only skin care product for a period of 8 weeks.
Skin firmness and elasticity are measured on day 0 and again after 8 weeks. Both measurements are taken in a room with a temperature of 20 ± 2 °C and a humidity of 50 ± 10%, so that the results are not influenced by the environment. The measurement results are then compared before and after the 8 weeks of use of the test product.
In the clinical study, the effect of the test product is compared in this way with the skin care that the test subject used before the study.
The test is in accordance with:
- Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products
- Cosmetics Europe – The Personal Care Association (formerly COLIPA) guidelines:
"Product Test Guidelines for the Assessment of Human Skin Compatibility" (1997)
- Cosmetics Europe – The Personal Care Association (formerly COLIPA) guidelines for evaluating the efficacy of cosmetic products (2008)
Wrinkle length and wrinkle depth can be measured using the Visioline® VL 650 measuring instrument. The measuring principle is based on replicating the skin’s relief – and thus the wrinkles – using a material called Silflo® . The wrinkles, which normally go deep into the skin, will appear on the replica as microscopic “mountains” that rise up. These “mountains” are illuminated at a special angle, so that shadows are formed. The shadows are measurable and visualized using a camera. The measured shadows are used as a basis in mathematical models, which provides quantitative measurements of wrinkle parameters such as depth and length.
Method
The test subjects are instructed to stop using other face creams, serums, etc. at the start of the test period. The test subjects apply the test product to their face twice daily as their only skin care product for 8 weeks.
Wrinkle parameters are measured on day 0 and again after 8 weeks. Both measurements are taken in a room with a temperature of 20 ± 2 °C and a humidity of 50 ± 10%, so that the results are not affected by the environment. The measurement results are then compared before and after the 8 weeks of use of the test product.
In the clinical study, the effect of the test product is compared in this way with the skin care that the test subject used before the study.
The test is in accordance with:
- Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products
- Cosmetics Europe – The Personal Care Association (formerly COLIPA) guidelines:
"Product Test Guidelines for the Assessment of Human Skin Compatibility" (1997)
- Cosmetics Europe – The Personal Care Association (formerly COLIPA) guidelines for evaluating the efficacy of cosmetic products (2008)*
STUDIES
The study complies with several guidelines and regulations, including:
- European Parliament and Council Regulation (EC) No. 1223/2009 on cosmetic products.
- Cosmetics Europe Guidelines for Human Skin Compatibility (1997), Efficacy of Cosmetic Products (2008), and Product Claim Substantiation (2019).
Investigational Product:
- Product Reference: DR.ANKERSTJERNE ANTI-AGE NIGHTCREAM
- Intended Use: Skin care
- Method of Use: Apply to face in the morning and before bedtime.
- Contraindications: Acute inflammation requiring pharmacological treatment and allergy or hypersensitivity to any ingredients.
Study Description:
- Aim: To confirm or exclude the declared efficiency of the product.
- Duration: 42 days (+/- 2 days)
Testing Methodology:
Instrumental Test of Skin Firmness and Elasticity (Cutometer® MPA 580):
- Objective: To measure the impact of the product on skin firmness and elasticity.
- Subjects: 27 women aged 35-65 with normal, dry, sensitive, and non-sensitive skin types.
- Procedure: Measurements before product application (D0) and after 42 days (D42) of regular use.
- Environment: Air-conditioned room at 20±2°C and relative humidity 50±10%.
Wrinkles Analysis (Primos 3D Lite):
- Objective: To assess wrinkle length, depth, count, volume, and area.
- Procedure: Measurements before product application (D0) and after 42 days (D42) of regular use.
- Environment: Air-conditioned room at 20±2°C and relative humidity 50±10%.
- Statistical Analysis:
- Performed using STATISTICA 13.
- Paired sample T test or Wilcoxon signed rank test was used.
- Significance level set at p<0.05.
Results:
- Skin Firmness and Elasticity:
- Elasticity Improvement: 96% of subjects showed improvement with an average increase of 9% (statistically significant).
- Firmness Improvement: 100% of subjects showed improvement with an average decrease of 15% in the parameter value (statistically significant).
- Wrinkle Analysis:
- Length Reduction: 88% of subjects showed a decrease with an average reduction of 4% (statistically significant).
- Wrinkle Count Reduction: 92% of subjects showed a decrease with an average reduction of 8% (statistically significant).
- Volume Reduction: 80% of subjects showed a decrease with an average reduction of 6% (statistically significant).
- Wrinkle Area Reduction: 88% of subjects showed a decrease with an average reduction of 3% (statistically significant).
Conclusion:
After 42 days of regular use, the DR.ANKERSTJERNE ANTI-AGE NIGHTCREAM:
- Improves Skin Elasticity and Firmness: Statistically significant improvements.
- Reduces Wrinkles Length and Depth: Statistically significant reduction in length.
- Reduces Wrinkle Count, Volume, and Area: Statistically significant reductions.
This report confirms the efficacy of the DR.ANKERSTJERNE ANTI-AGE NIGHTCREAM based on instrumental tests.
The study adhered to several regulatory and guideline frameworks, including:
- European Parliament and Council Regulation (EC) No. 1223/2009 on cosmetic products.
- Guidelines from Cosmetics Europe (formerly COLIPA).
Investigational Product
- Products Tested : DR.ANKERSTJERNE SUPERFOOD MULTIPURPOSE VITAMIN FACEGEL and DR.ANKERSTJERNE URBAN PROTECTION DAYCREAM.
- Intended Use : Skin care.
- Method of Use : First apply the face gel, followed by the day cream after 1-2 minutes.
Study Description
- Aim : To confirm or exclude the declared efficiency of the products.
- Duration : 42 days (+/- 2 days).
- Subjects : 52 women aged 35-65 with normal, dry, non-sensitive skin.
Testing Methodology
Instrumental Test of Skin Elasticity and Firmness :
- Measured using Cutometer® MPA 580.
- Conducted on 52 subjects, measurements taken before (D0) and after 42 days (D42) of regular use.
- Conducted in controlled conditions (20±2°C, relative humidity 50±10%).
Wrinkle Analysis :
- Measured using Primo's 3D Lite.
- Evaluated wrinkle length, depth, count, volume, and area.
- Conducted on 52 subjects, measurements taken before (D0) and after 42 days (D42) of regular use.
- Statistical Analysis :
- Used STATISTICA 13, employing Paired sample T test or Wilcoxon signed rank test.
- Significance level set at p<0.05.
Results
Skin Elasticity :
- Statistically significant improvement (p-value = 0.0000).
- 100% of subjects showed a positive effect.
Skin Firmness :
- Statistically significant improvement (p-value = 0.0000).
- 96% of subjects showed a positive effect.
Wrinkle Length :
- Statistically significant reduction (p-value = 0.0000).
- 78% of subjects showed a positive effect.
Wrinkle Depth :
- Statistically significant reduction (p-value = 0.0054).
- 67% of subjects showed a positive effect.
Wrinkle Count :
- Statistically significant reduction (p-value = 0.0000).
- 96% of subjects showed a positive effect.
Wrinkle Volume :
- Statistically significant reduction (p-value = 0.0002).
- 69% of subjects showed a positive effect.
- Wrinkle Area :
- Statistically significant reduction (p-value = 0.0000).
- 84% of subjects showed a positive effect.
Conclusion
Under the study conditions, after 42 days of regular use, the products DR.ANKERSTJERNE SUPERFOOD MULTIPURPOSE VITAMIN FACEGEL and DR.ANKERSTJERNE URBAN PROTECTION DAYCREAM:
- Significantly improved skin elasticity by an average of 11%.
- Significantly improved skin firmness by an average of 13%.
- Reduced wrinkle count by an average of 9%.
- Significantly reduced wrinkle length, depth, volume and wrinkle area
These results confirm the efficacy of the products in enhancing skin biomechanical properties and reducing various aspects of wrinkles. The detailed results, methodology, and compliance ensure the reliability and validity of the findings, supporting the claimed benefits of the investigated skin care products.
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